VIRAL EVASION OF INNATE IMMUNE DEFENSE: THE CASE OF RESISTANCE OF PANDEMIC H1N1 INFLUENZA A VIRUS TO HUMAN MANNOSE-BINDING PROTEINS

Viral Evasion of Innate Immune Defense: The Case of Resistance of Pandemic H1N1 Influenza A Virus to Human Mannose-Binding Proteins

Mannose-binding lectins effectively inhibit most seasonal strains of influenza A virus and contribute to the innate host defense vs.these viruses.In contrast, pandemic IAV strains are largely resistant to these lectins, likely contributing to increased spread and worse outcomes.In this paper, we evaluated the inhibition of IAV by mannose-binding le

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In silico assessment of biocompatibility and toxicity: molecular docking and dynamics simulation of PMMA-based dental materials for interim prosthetic restorations

Abstract Aim: This study aimed to comprehensively assess the biocompatibility and toxicity profiles of poly(methyl methacrylate) (PMMA) and its monomeric unit, methyl methacrylate (MMA), crucial components in dental materials for interim prosthetic restorations.Methodology: Molecular docking was employed to predict the binding affinities, energetic

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Acute Severe Cushing Syndrome: Not Always Ectopic Acth Syndrome

ABSTRACT: Objective: Cushing syndrome (CS) is a rare disease that results from prolonged supraphysiologic tissue action of glucocorticoids.Cushing disease is the most frequent cause of endogenous CS and is associated with increased morbidity and mortality.Disease onset and severity reflects the magnitude of cortisol excess, and ectopic adrenocortic

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