Viral Evasion of Innate Immune Defense: The Case of Resistance of Pandemic H1N1 Influenza A Virus to Human Mannose-Binding Proteins
Mannose-binding lectins effectively inhibit most seasonal strains of influenza A virus and contribute to the innate host defense vs.these viruses.In contrast, pandemic IAV strains are largely resistant to these lectins, likely contributing to increased spread and worse outcomes.In this paper, we evaluated the inhibition of IAV by mannose-binding le